SALL3, a New Member of the Human spalt -like Gene Family, Maps to 18q23
Identifieur interne : 000B76 ( Main/Exploration ); précédent : 000B75; suivant : 000B77SALL3, a New Member of the Human spalt -like Gene Family, Maps to 18q23
Auteurs : Jürgen Kohlhase [Allemagne] ; Susanna Hausmann [Allemagne] ; Goran Stojmenovic [Allemagne] ; Christa Dixkens [Allemagne] ; Karin Bink [Allemagne] ; Walter Schulz-Schaeffer [Allemagne] ; Mariele Altmann [Allemagne] ; Wolfgang Engel [Allemagne]Source :
- Genomics [ 0888-7543 ] ; 1999.
Abstract
spalt (sal) of Drosophila melanogaster is an important developmental regulator gene and encodes a zinc finger protein of unusual but characteristic structure. Two human sal-like genes have been isolated so far, SALL1 on chromosome 16q12.1 and SALL2 on chromosome 14q11.1–q12.1. Truncating mutations of SALL1 have been shown to cause Townes–Brocks syndrome and are thought to result in SALL1 haploinsufficiency. Sequence comparison of SALL1 to the related genes Msal in mouse and Xsal-1 in Xenopus laevis suggested that SALL1 was not the human orthologue of Msal and Xsal-1. By database searching and genomic cloning, we isolated an EST and a corresponding human cosmid clone, which contain coding sequence of a human gene highly similar to mouse Msal. This gene, named SALL3, was found to be expressed in different regions of human fetal brain and in different adult human tissues. The chromosomal localization of SALL3 at 18q23 suggests that haploinsufficiency of this gene might contribute to the phenotype of patients with 18q deletion syndrome.
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DOI: 10.1006/geno.1999.6005
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Two human sal-like genes have been isolated so far, SALL1 on chromosome 16q12.1 and SALL2 on chromosome 14q11.1–q12.1. Truncating mutations of SALL1 have been shown to cause Townes–Brocks syndrome and are thought to result in SALL1 haploinsufficiency. Sequence comparison of SALL1 to the related genes Msal in mouse and Xsal-1 in Xenopus laevis suggested that SALL1 was not the human orthologue of Msal and Xsal-1. By database searching and genomic cloning, we isolated an EST and a corresponding human cosmid clone, which contain coding sequence of a human gene highly similar to mouse Msal. This gene, named SALL3, was found to be expressed in different regions of human fetal brain and in different adult human tissues. The chromosomal localization of SALL3 at 18q23 suggests that haploinsufficiency of this gene might contribute to the phenotype of patients with 18q deletion syndrome.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Göttingen</li></settlement><orgName><li>Université de Göttingen</li></orgName></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Kohlhase, Jurgen" sort="Kohlhase, Jurgen" uniqKey="Kohlhase J" first="Jürgen" last="Kohlhase">Jürgen Kohlhase</name></region><name sortKey="Altmann, Mariele" sort="Altmann, Mariele" uniqKey="Altmann M" first="Mariele" last="Altmann">Mariele Altmann</name><name sortKey="Bink, Karin" sort="Bink, Karin" uniqKey="Bink K" first="Karin" last="Bink">Karin Bink</name><name sortKey="Dixkens, Christa" sort="Dixkens, Christa" uniqKey="Dixkens C" first="Christa" last="Dixkens">Christa Dixkens</name><name sortKey="Engel, Wolfgang" sort="Engel, Wolfgang" uniqKey="Engel W" first="Wolfgang" last="Engel">Wolfgang Engel</name><name sortKey="Hausmann, Susanna" sort="Hausmann, Susanna" uniqKey="Hausmann S" first="Susanna" last="Hausmann">Susanna Hausmann</name><name sortKey="Schulz Schaeffer, Walter" sort="Schulz Schaeffer, Walter" uniqKey="Schulz Schaeffer W" first="Walter" last="Schulz-Schaeffer">Walter Schulz-Schaeffer</name><name sortKey="Stojmenovic, Goran" sort="Stojmenovic, Goran" uniqKey="Stojmenovic G" first="Goran" last="Stojmenovic">Goran Stojmenovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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